Reaction Kinetics and Mechanistic Studies of the Rh-Catalyzed Asymmetric Hydrogenation with MonoPhosTM
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چکیده
In this chapter the results of kinetic studies of the rhodium-catalyzed asymmetric hydrogenation using monodentate phosphoramidite ligands are described. Together with the data obtained by a number of other techniques a mechanism for the Rhcatalyzed asymmetric hydrogenation with MonoPhosTM is proposed. The formation of the catalyst precursor results in a mixture of diastereomeric Rh-complexes which were determined by NMR techniques. The Halpern mechanism is proposed to be the most likely mechanism for the asymmetric hydrogenation based on the kinetic measurements.
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